Genetic Epidemiology of Mammographic Breast Density
Annual rept. 1 Oct 1998-30 Sep 1999
MAYO FOUNDATION ROCHESTER MN
Pagination or Media Count:
Mammographic percent density is an established and important risk factor for breast cancer. We have previously shown that this risk factor has a considerable genetic component that may be the result of a single major gene. We are now working to localize this gene to an autosome. Simulation studies were performed on all study families n426. We identified 57 families in which multiple members have previously obtained mammograms. Primary efforts are to obtain DNA samples on these family members. To date, letters of invitation consent forms have been sent to more than half n 264 of the study women. A total of 189 have agreed, 31 declined participation, 16 were deceased, 4 are in a nursing home, and 24 have yet to be contacted. Of the blood kits that have been mailed, 144 have already been returned. Isolation of DNA from peripheral blood for genetic analysis has been on-going as the samples get delivered to the Molecular Genetics Laboratory at the Mayo Clinic. Genotyping, analysis, and preparation of reports will not begin until all of the DNA samples have been collected. In summary, it is still early in the conduct of this research study but progress is being made according to the proposed timeline.
- Anatomy and Physiology
- Medicine and Medical Research