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A Cohort Study of the Relationship Between c-erbB-2 and Cyclin D1 Overexpression, p53 Mutation and/or Protein Accumulation, and Risk of Progression From Benign Breast Disease to Breast Cancer; and Creation of a Bank of Benign Breast Tissue

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Annual rept. 13 Sep 1998-13 Sep 1999

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We recently completed a case-control study nested within a cohort of 4,888 women with benign breast disease BBD who participated in the National Breast Screening Study NBSS. This showed that accumulation of p53 protein was associated with an increased risk of progression to breast cancer adjusted odds ratio OR 2.55 95 confidence interval CI 1.01-6.40, whereas c-erbB-2 protein overexpression was not adjusted OR 0.65 95 CI 0.27-1.53. In this grant, we proposed to 1 collect paraffin-embedded breast tissue the remaining 4,336 that is 4,888-552 cohort members 2 enlarge our ongoing case-control study with an additional 63 cases and their controls which were identified as a result of a linkage of the NBSS database to the Canadian Cancer Database 3 examine whether cyclin Dl gene amplification or protein overexpression determined immmunohistochemically is a biomarker of increased risk of breast cancer. To date, we have updated the data base and are collecting blocks for the remaining cohort members. Our initial analysis suggests that cyclin Dl overexpression, as detected immunohistochemically, does not appear to be associated with increased risk of developing breast cancer OR 1.2 CI 0.65-2.29 in the individuals studied to date. Further analysis is ongoing. This study will be expanded when the additional cases are identified by the linkage described above.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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