Characterization of BC1-2, BC1-XL, and Bax Pore Formation and Their Role in Apoptosis Regulation
Annual summary rept. 1 Jul 1998-30 Jun 1999
BURNHAM INST LA JOLLA CA
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The Bcl-2 protein family plays an important role in governing a cells decision to live or die. Dysregulation of these proteins is observed in many breast cancer cases and thus it is important to understand their mechanism in order to develop new treatments. The Bcl-XL protein structure showed a strong similarity to pore-forming bacterial toxins, suggesting that Bcl-2 protein - family protein may regulate apoptosis by pore formation or membrane insertion. The results obtained this year include characterization of membrane binding of these proteins to lipid vesicles.
- Medicine and Medical Research