Gene Transfer Studies of the Pathogenesis and Treatment of Parkinson's Disease
Annual rept. 1 Aug 1999-31 Jul 2000
PITTSBURGH UNIV PA
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The overall aim of this research is to use a recombinant multiply deleted genomic herpes simplex virus type-i HSV-l based gene transfer vector to test the hypotheses that gene transfer of the glial derived neurotrophic factor GDNF or bcl-2 can slow or prevent the apoptotic death of nigral neurons in animal models of PD, and that expression of tyrosine hydroxylase TH can improve symptoms.
- Medicine and Medical Research