Accession Number:

ADA383307

Title:

Gene Transfer Studies of the Pathogenesis and Treatment of Parkinson's Disease

Descriptive Note:

Annual rept. 1 Aug 1999-31 Jul 2000

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

Report Date:

2000-08-01

Pagination or Media Count:

35.0

Abstract:

The overall aim of this research is to use a recombinant multiply deleted genomic herpes simplex virus type-i HSV-l based gene transfer vector to test the hypotheses that gene transfer of the glial derived neurotrophic factor GDNF or bcl-2 can slow or prevent the apoptotic death of nigral neurons in animal models of PD, and that expression of tyrosine hydroxylase TH can improve symptoms.

Subject Categories:

  • Psychology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE