The Role of Parathyroid Hormone-Related Protein in Breast Cancer Mediated Osteolysis
Final rept. 30 Sep 1994-29 Sep 1999
TEXAS UNIV AT SAN ANTONIO
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Breast cancer affects the skeleton through humoral and local osteolytic mechanisms to cause the devastating complications of hypercalcemia, pain, fracture and nerve compression syndromes. PTHrP mediates hypercalcemia through its systemic effects to increase osteoclastic bone resorption as well as renal tubular calcium reabsorption in at least 50 of hypercalcemic breast cancer patients even in the presence of bone metastases. Due to this potent bone resorbing capacity, PTHrP expression in the primary tumor may aid in establishment of the bone metastases that are characteristic of patients with breast cancer. This final report summarizes the findings of the funding period. 50 of breast cancer cell lines tested secrete low, but significant amounts of PTHrP.
- Medicine and Medical Research