Accession Number:

ADA383256

Title:

The Role of Parathyroid Hormone-Related Protein in Breast Cancer Mediated Osteolysis

Descriptive Note:

Final rept. 30 Sep 1994-29 Sep 1999

Corporate Author:

TEXAS UNIV AT SAN ANTONIO

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

112.0

Abstract:

Breast cancer affects the skeleton through humoral and local osteolytic mechanisms to cause the devastating complications of hypercalcemia, pain, fracture and nerve compression syndromes. PTHrP mediates hypercalcemia through its systemic effects to increase osteoclastic bone resorption as well as renal tubular calcium reabsorption in at least 50 of hypercalcemic breast cancer patients even in the presence of bone metastases. Due to this potent bone resorbing capacity, PTHrP expression in the primary tumor may aid in establishment of the bone metastases that are characteristic of patients with breast cancer. This final report summarizes the findings of the funding period. 50 of breast cancer cell lines tested secrete low, but significant amounts of PTHrP.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE