Role of the Wnt-4 Protein in the Mouse Mammary Gland
Annual rept. 1 Jul 1998-30 Jun 1999
PENNSYLVANIA UNIV PHILADELPHIA
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The subject of the research described within this report is the mouse Brca1 protein. The primary purpose of the experiments outlined below is to further the understanding of the role the mouse Brca1 protein in cell proliferation and DNA damage. The scope of this research encompasses experiments that are designed to determine if the mouse and human BRCA1 proteins govern similar cellular functions and aims to identify novel regulatory components implicated in BRCA1-derived cancers through the use of a genetic model system in which mouse BRCA1 is mutated. Lastly, an immortalized mouse embryonic fibroblast cell line that harbors an exon 11 mutant form of BRCA1 has been generated. This is significant because it provides a novel system which is suited for biochemical analysis of mouse BRCA1 function.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research