Cytokines, Neovascularization and Breast Cancer
Final rept. 1 Octg 1994-30 Sep 1998
CONNECTICUT UNIV HEALTH CENTER FARMINGTON
Pagination or Media Count:
Angiogenesis is critical for tumor growth and metastasis. The relationship between the degree of tumor angiogenesis and poor outcome has been reported. Little is known about the regulation of this process. Our general hypothesis is that tumors behave like wounds that heal in an abnormal fashion. Angiogenesis is a normal component of wound healing. Thus, we investigated whether cytokines that regulate wound healing would also be found in human breast cancer. Interleukin 8 IL-8 is an inflammatory cytokine that is also a known angiogenic factor. The goals of this project were to 1 establish the presence of IL-S in human breast cancer samples 2 investigate whether human breast cancer cells produce IL-8 in an in vitro model and dissect the factors that regulate that process and 3 develop an in vivo model of human breast cancer in immnunodeficient model and attempt to block angiogenesis generally and IL-8 specifically in order to slow tumor growth. The first two goals have been met, the third has not. Much of the data generated has been presented in earlier Annual Reports. Other data has been published, presented or is in manuscript.
- Anatomy and Physiology
- Medicine and Medical Research