Accession Number:

ADA383220

Title:

Modulation of Molecular Markers by CLA

Descriptive Note:

Final rept. 14 Sep 1994-13 Sep 1999

Corporate Author:

AMC CANCER RESEARCH CENTER DENVER CO

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

109.0

Abstract:

Conjugated linoleic acid CLA is a potent inhibitor of experimentally-induced mammary carcinogenesis. Both chemically pure as well as naturally occurring forms of CLA exert this cancer preventive activity. While CLA can reduce levels of lipid peroxidation in the mammary gland, this apparent antioxidant effect may be secondary to a primary effect on CLA on suppressing the metabolism of linoleic acid. Suppression of linoleic acid metabolism may also account for the effects of CLA in decreasing mammary gland density and in inhibiting rates of cell proliferation in structural elements of the mammary gland that are targets for neoplastic transformation. Collectively, these data justify additional pre-clinical and clinical studies to evaluate the safety and efficacy of CLA for the prevention of human breast cancer.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE