Accession Number:

ADA383147

Title:

Therapeutic Resistance of Prostate Cancer Mediated by Cadherin T6

Descriptive Note:

Annual rept. 1 Oct 1998-30 Sep 1999

Corporate Author:

COLUMBIA UNIV NEW YORK

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

24.0

Abstract:

In order to better understand the molecular basis for the development of therapeutic resistance by prostate cancer, we have undertaken experimentation in which we genetically compared therapy resistant prostate cancer cells to therapy sensitive prostate cancer cells. As a result of this comparison, we have identified a novel gene product, previously referred to as T6 now referred to as Protocadherin-PC that is highly upregulated when prostate cancer cells are selected for resistance to apoptotic agents in vitro and when these cells are selected for hormonal resistance in vivo. This progress report describes our success in characterizing the human Protocadherin-PC gene and gene product and in describing the probable mechanism through which this protein increases therapeutic resistance of prostate cancer cells. As a result of these studies, we believe that prostate cancer progresses to the state of therapeutic resistance in a mechanistically similar manner to that of human colon cancer and melanoma.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE