Accession Number:

ADA383088

Title:

Network Interaction of erbB, neu-erb2, erbB3, erbB4, in the Biological Response to NDF/heregulins

Descriptive Note:

Final rept. 28 Sep 1994-27 Sep 1999,

Corporate Author:

YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

92.0

Abstract:

The gene encoding the neuerB-2HER-2 receptor tyrosine kinase is one of a small number of genes known to be altered in human breast and ovarian carcinoma. It is amplified andor over expressed in approximately one-fourth of these cancers. With its probable role in etiology, and expression at the cell surface, neu has great potential as a prognostic indicator and therapeutic target. Efforts to exploit this receptor in the clinical arena have been impeded by the failure to consider regulation of neu by hormones and co-receptors. this has been complicated by the fact that at least seven different peptide hormones, epidermal growth factor EGF, transforming growth factor-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth, epiregulin, and the diverse neuregulins are all able to activate neu.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE