How do Genetic Determinants of Bone Mass Relate to Breast Cancer Risk?
Annual rept. 1 Aug 1998-1 Aug 1999
WAYNE STATE UNIV DETROIT MI
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The purpose of this study is to investigate the relationship between breast cancer risk, bone mass, and two polymorphic hormone receptor genes-- the estrogen receptor ER and vitamin D receptor VDR genes. We will also explore a possible functional mechanism to explain this association. We will recruit 200 new breast cancer cases and 200 controls, ages 40-85, with equal numbers of African-Americans and whites. Bone mineral density BMD measurements of the forearm will be obtained. We have enrolled 121 women 53 white and 20 African-American breast cancer, and 27 white and 21 African- American controls, with an age range of 40-81. We have increased monthly recruitment from 7 per month in the first 3 months to an average of 19 subjects per month in the past 3 months, which should allow accrual of 400 subjects as planned.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research