Growth Inhibition of Breast Tumor Cells by Hypodense and Normodense Eosinophilic Cell Lines
Annual rept. 15 Jun 1998-14 Jun 1999
HOWARD UNIV WASHINGTON DC
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We have shown that cell lines developed from metrizamide density gradient fractions of peripheral blood hypodense BJA.060.22 and hyperdense BJA.060.24 eosinophils significantly inhibited MCF-7 colony formation in a dose-dependent fashion with as much as 82 inhibition ocurring at the ET ratio of 1000 1 BJA.060.22 and 85 inhibition of MDA-MB-231 cells at the same ET ratio. At 10001 ET ratio, the hyperdense eosinophil cell line BJA.060.24 inhibited MCF-7 colony formation by half that of the hypodense line 44 and MDA-MB-231 colony formation by 70.
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