The p16 Pathway in Breast Cancer and Senescence Control
Annual rept. 1 Sep 1998-31 Aug 1999
M D ANDERSON CANCER CENTER HOUSTON TX
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Abnormalities affecting the INK4A locus are common in breast cancer. Disregulation of expression of the genes encoded by such locus p16 and p14 to the ARF affects most breast carcinomas. Overexpression of p16 associates with more aggressive breast cancer frequently. On the other hand, p16 inactivation is a key necessary event that HMEC use to achieve extended life in vitro and to overcome the MO senescence arrest. Future studies will address whether p14 to the ARF neutralization couples with p16 inactivation in HMBC are sufficient to achieve in vitro immortality.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research