Signal Transduction and Gene Regulation During Hypoxic Stress: A Potential Role in Neurodegenerative Disease
Annual rept. 9 Jul 1999-8 Jul 2000
CINCINNATI UNIV OH
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The primary objective of this research project is to determine the role of the mitogen-activated protein kinase MAPK pathways specifically p38 kinase in mediating the cellular response to hypoxia-stress. The overall scope of this project is to understand how neurons adapt to chronic hypoxia. The neural-like PC12 cell line is used as a model system to identify the molecular mechanisms that mediate tolerance to hypoxia. The inability to develop tolerance can lead to neurodegeneration and possibly cell death. Our work on this project resulted in the publication of 4 original papers, 1 review paper, and 1 book chapter.
- Medicine and Medical Research
- Stress Physiology