Inhibition of Mammary Cancer by Citrus Limonoids
Annual rept. 1 Aug 1998-31 Jul 1999
UNIVERSITY OF WESTERN ONTARIO LONDON
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Citrus limonoids are a class of chemically related compounds present in lemon, lime, orange and grapefruit. We have shown that nomilin and a limonoid glucoside mixture are potent inhibitors of proliferation of estrogen receptornegative ER- and -positive ER human breast cancer cells in culture. In the present experiments, we tested deacetylnomilin, deoxylimonin, ichangin, isoobacunoic acid, limonol, limonin carboxyrnethoxime, methyl deoxylimonate, methylnomilinate, methyl deacetylnomilinate, methyl isolimonate, nomilin glucoside, nomilinic acid glucoside, 7a-obacunol, obacunone and obacunone glucoside for their ability to inhibit the proliferation of MDA-MB-435 ER- and MCF-7 ER human breast cancer cells.
- Medicine and Medical Research