Accession Number:

ADA383033

Title:

Inhibition of Mammary Cancer by Citrus Limonoids

Descriptive Note:

Annual rept. 1 Aug 1998-31 Jul 1999

Corporate Author:

UNIVERSITY OF WESTERN ONTARIO LONDON

Personal Author(s):

Report Date:

1999-08-01

Pagination or Media Count:

17.0

Abstract:

Citrus limonoids are a class of chemically related compounds present in lemon, lime, orange and grapefruit. We have shown that nomilin and a limonoid glucoside mixture are potent inhibitors of proliferation of estrogen receptornegative ER- and -positive ER human breast cancer cells in culture. In the present experiments, we tested deacetylnomilin, deoxylimonin, ichangin, isoobacunoic acid, limonol, limonin carboxyrnethoxime, methyl deoxylimonate, methylnomilinate, methyl deacetylnomilinate, methyl isolimonate, nomilin glucoside, nomilinic acid glucoside, 7a-obacunol, obacunone and obacunone glucoside for their ability to inhibit the proliferation of MDA-MB-435 ER- and MCF-7 ER human breast cancer cells.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE