Regulation of The Tumor Suppressor Activity of P53 In Human Breast Cancer
Annual rept. 1 Aug 1998-1 Aug 1999
MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
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This research is centered on testing the hypothesis that there are novel mechanisms in human breast cancer involving functional inactivation of wild-type p53 besides such direct genetic alteration. The immediate goal of this research is to characterize cellular activities which affect the ability of p53 to bind to DNA in a sequence-specific manner. The long term goal is to determine the relevance of such regulators in human breast cancer. Human breast tumor samples would be screened for alterations in the expression of these proteins which affect the DNA binding activity of p53. The identification of proteins which regulate wild-type p53 is an important focus for breast cancer research since the regulation, mechanism of action, and metabolism of such proteins would be central to our understanding of breast cancer and the aberrant expression of such proteins would represent novel important mechanisms of carcinogenesis.
- Medicine and Medical Research