Estrogen Receptor Gene Polymorphisms and Breast Cancer Risk
Annual rept. 15 Sep 1998-15 Nov 1999
UPPSALA UNIV (SWEDEN)
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TO TEST THE HYPOTHESIS THAT INDIVIDUAL VARIATION IN THE SENSITIVITY TO ESTROGENS, WHETHER FROM ENDOGENOUS OR EXOGENOUS SOURCES, AFFECTS WOMAN 5 RISK OF BREAST CANCER. Scope to test ithe variability in responses to estrogens in women may be determined by a functionally significant variation in the estrogen receptor alpha ER though which estrogens exert biologic effects. The ER polymorphisms under study are xba I, Pvu II and microsatelite polymorphisms. In an exploratory analysis we will study the interaction between the Xba I Pvu II and microsatellite ER polymorphisms and estrogen-related risk factors for breast cancer such as reproductive history and menopausal hormone use.
- Anatomy and Physiology
- Medicine and Medical Research