Mammary Gland Ontogeny and Neoplasia in Oxytocin Deficient Mice
Annual rept. 1 Jul 1998-30 Jun 1999
PITTSBURGH UNIV PA
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The hormonal environment in which mammary tumors develop and are maintained is important for understanding not only the progression, but also the potential strategies for treatment, of breast cancer. A possible role for endogenous oxytocin OT in human breast cancer has not been extensively studied. OT functions as both a hormone and neuropeptide. In the periphery, OT contracts the myoepithelial cells of the breast to elicit milk ejection during lactation and the myometrial cells of the uterus at parturition. Mammary myoepithelial cells and uterine myometrial cells express receptors for OT OTR, which mediate its contractile effects within these cells. The OTR is a seven transmembrane domain polypeptide that belongs to the family of G protein-coupled receptors.
- Anatomy and Physiology
- Medicine and Medical Research