Determination of the Crystal Structure of Human Zn-Alpha 2-Glycoprotein, A Protein Implicated in Breast Cancer
Annual rept. 1 Aug 1998-31 Jul 1999
CALIFORNIA INST OF TECH PASADENA
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Zn-alpha- 2-glycoprotein ZAG is a soluble protein that is present in serum and other body fluids. In addition, ZAG accumulates in breast cysts as well as in 40 of breast carcinomas. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 Angstrom crystal structure of ZAG resembles a class I major histocompatibility complex MHC heavy chain, but ZAG does not bind the class I light chain beta-2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a non-peptidic compound that may be implicated in lipid catabolism under normal or pathological conditions.
- Medicine and Medical Research