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Accession Number:
ADA379853
Title:
Effect of Hypercholesterolernia on Cutaneous Vascular Responses to Exercise in Healthy, Exercise-Trained, Heat-Acclimated Humans
Descriptive Note:
Technical rept.
Corporate Author:
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
Report Date:
2000-07-01
Pagination or Media Count:
28.0
Abstract:
The purpose of this research was to determine whether healthy, exercise-trained, heat-acclimated people with one major risk factor for coronary artery disease high total cholesterolhigh-density lipoprotein cholesterol TCHDL-C would have different cutaneous vascular responses to exercise in a warm environment compared to people who were of similar age and gender who did not share the risk factor. It was hypothesized that individuals who had an elevated TCHDL-C would have similar deleterious effects on the cutaneous vasculature as the coronary arteries and aorta as observed in pathological studies. That is, individuals who have a high TCHDL-C ratio might have less compliant cutaneous vessels and therefore impaired sensible heat loss than individuals who have a low TCHDL-C ratio. In the current study, we measured cutaneous vascular responses using noninvasive instruments during rest and exercise in a warm environment in individuals with either a high or low TCHDL-C ratio. Obtaining evidence for impaired heat dissipation was limited by the conservative study design because the volunteers were studied in a moderately hot environment with a moderate humidity rather than a hot environment because half of the study population, by definition, was at risk for coronary artery disease. Subjects in both groups routinely exercised and were heat-acclimated.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
