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Accession Number:
ADA379789
Title:
Telemetric Evaluation of Body Temperature and Physical Activity as Predictors of Mortality in a Murine Model of Staphylococcal Enterotoxic Shock.
Descriptive Note:
Scientific Paper
Corporate Author:
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Report Date:
2000-07-19
Pagination or Media Count:
8.0
Abstract:
Background and Purpose Hypothermia and death are used as experimental markers in murine models of staphylococcal enterotoxins shock. This study determined whether body temperature and physical activity, monitored telemetrically, could predict impending death and provide an earlier, more humane experimental endpoint. Methods The study consisted of two iterations experiments 1 and 2 to determine reproducibility of the model. Each experiment consisted of 24 BALBIc mice surgically implanted with intra-abdominal telemetry transmitters lipopolysaccharide LPS. Core body temperature and physical activity were continuously monitored in all mice for 10 days before, and 5 days after, injections. Additionally, in experiment 2, subcutaneous temperatures were compared with core body temperatures obtained by telemetry. Results Body temperature and physical activity were reduced in mice after administration of SEB and LPS, or LPS alone, but not SEB only. There was a significant P O.05correlation between mortality and body temperature P 0.0077, but not physical activity PO.97. Conclusion Body Temperature proved to be an early indicator of mortality in this murine model of staphylococcal enterotoxins shock.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
