Accession Number:

ADA379649

Title:

Using Mode of Action of Assess Health Risks From Mixtures of Chemical/Physical Agents

Descriptive Note:

Annual rept.

Corporate Author:

AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH

Personal Author(s):

Report Date:

1998-12-01

Pagination or Media Count:

16.0

Abstract:

Mixtures of carcinogenic chemicals are a major problem in ground water and soils on DoD and DOE facilities. While there is frequently data available for interactions between chemicals to judge risks from short term exposures, data that describe how interactions influence the development of cancer are very rare. This is largely because of the high cost associated with conducting complex interaction studies over the lifetime of experimental animals. Therefore, it is important that the limited resources that are available for studying interactions be directed towards the development of general principles that can be applied to wide variety of circumstances. The co-occurrence of chlorinated solvents at DoD and DOE facilities such as trichloroethylene TCE, tetrachloroethylene PERC and carbon tetrachloride CT is a case in point.

Descriptors:

• *HEALTH
• *TOXIC AGENTS
• *CARCINOGENS
• CHEMICALS
• TOXICITY
• GROUND WATER
• CANCER
• TRICHLOROETHYLENE
• ETHYLENES
• CHLORINE COMPOUNDS
• CARBON TETRACHLORIDE

Subject Categories:

• Medicine and Medical Research
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE