Accession Number:

ADA379302

Title:

Biology of Somatostatin and Somatostatin Receptors in Breast Cancer

Descriptive Note:

Annual rept. 12 Aug 1998-11 Aug 1999

Corporate Author:

MCGILL UNIV MONTREAL (QUEBEC)

Personal Author(s):

• Patel, Yogesh C.

Report Date:

1999-09-01

Pagination or Media Count:

138.0

Abstract:

Analysis of SSTR1-5 mRNA expression by semiquantitative RT-PCR in two separate batches of primary ductal NOS breast cancer n, N 48 and 50 has revealed a strong positive correlation p , 0.001 between SSTR3 expression and tumor grade suggesting that SSTR3 induction in high grade tumors may represent a compensatory mechanism for regulating proliferative activity through apoptosis. Expression of SSTR1, 2, and 4 strongly correlates with estrogen receptor levels and SSTR2 expression additionally correlates positively with progesterone receptor levels. Tamoxifen exhibits a dose-dependent biphasic effect on SSTR1 and SSTR5 mRNA, low doses being inhibitory and high doses being stimulatory.

Descriptors:

• *PEPTIDES
• *BREAST CANCER
• PROTEINS
• NEOPLASMS
• INHIBITION
• CELLS(BIOLOGY)
• RIBONUCLEIC ACIDS
• ANTIGENS
• PROGESTERONE
• ESTROGENS
• MITOCHONDRIA

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE