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Biology of Somatostatin and Somatostatin Receptors in Breast Cancer
Annual rept. 12 Aug 1998-11 Aug 1999
MCGILL UNIV MONTREAL (QUEBEC)
Pagination or Media Count:
Analysis of SSTR1-5 mRNA expression by semiquantitative RT-PCR in two separate batches of primary ductal NOS breast cancer n, N 48 and 50 has revealed a strong positive correlation p , 0.001 between SSTR3 expression and tumor grade suggesting that SSTR3 induction in high grade tumors may represent a compensatory mechanism for regulating proliferative activity through apoptosis. Expression of SSTR1, 2, and 4 strongly correlates with estrogen receptor levels and SSTR2 expression additionally correlates positively with progesterone receptor levels. Tamoxifen exhibits a dose-dependent biphasic effect on SSTR1 and SSTR5 mRNA, low doses being inhibitory and high doses being stimulatory.
APPROVED FOR PUBLIC RELEASE