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Breast Cancer Following Pediatric Hodgkins Disease: Risk Factors and Intervention

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Annual rept. 1 Jul 1998-30 Jul 1999

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Analysis of 1380 survivors of childhood Hodgkins disease HD has shown a 75-fold increased risk of breast cancer. The purpose of this proposal is to identify a sub-population among survivors of HD, at an increased risk for developing breast cancer. Construction of pedigrees of patients with secondary breast cancer did not reveal excess cancer among family members. We also planned to identify somatic andor germ line mutations in candidate genes such as p53, BRCA1 2, and ATM. Four of the six breast cancer samples examined so far, contained mutations in exons 5-9 of the p53 gene. Three of three blood samples examined for mutations in the ATM gene have shown no mutations. We are recommending a baseline mammogram at 25 years of age, repeated every three years till the age of 40, and then annually. For patients with an increased risk of breast cancer due to other risk factors, we recommend annual mammograms, beginning at age 25 years. We propose to institute these recommendations among a limited number of member institutions of the Children Cancer Group to address feasibility and compliance issues. In addition, we have initiated the process of updating the LESG cohort to identify new second cancers and associated risk factors.

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  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

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