Relation of Genes to Prostate Cancer Occurrence and Aggressiveness
Annual rept. 1 Jul 1998-30 Jun 1999
CASE WESTERN RESERVE UNIV CLEVELAND OH
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We are studying brothers with prostate cancer in order to investigate the potential relation between genetic factors and their disease. The brothers are being recruited into the study from registries at Case Western Reserve University, the Cleveland Clinic Foundation, and the Henry Ford Health System. We are contacting men who have been diagnosed with prostate cancer at these institutions to see if they have brothers and whether they would be willing to join our study. In the first year of the study we have contacted 723 men diagnosed with prostate cancer who were eligible for taking part in the study. We have successfully recruited 519 of these men into the 72 have been recruited into the study. This recruitment rate is close to our expected level. While recruitment progresses, we have also detected a positive association between a genetic polymorphism and prostate cancer aggressiveness among African-Americans. This work has led to a paper provisionally accepted for publication, which is attached in the Appendix. The corresponding result implicates such genes in the development andor aggressiveness of prostate cancer.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research