Accession Number:

ADA374727

Title:

Gene Therapy in a Nonhuman Primate Model of Parkinson's Disease.

Descriptive Note:

Annual rept. 15 Sep 98-14 Sep 99

Corporate Author:

RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER CHICAGO IL

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

26.0

Abstract:

This grant is studying the ability to deliver the trophic factor glial derived neurotrophic factor GDNF via in vivo and ex vivo viral vectors in nonhuman primates. In this first year, two studies have been performed and completed. In the first experiment, lentiviral vectors delivering the marker gene Beta galactosidase was injected into three monkeys to test the ability of this vector to demonstrate sustained expression in the nonhuman primate nigrostriatal system. This study revealed that robust and consistent gene expression could be achieved. In the second experiment, lentiviral delivery of GDNF was attempted in aged nonhuman primates. These injections resulted in a dramatic increase in dopaminergic markers in this model of early Parkinsons disease. These data indicate that lentiviral delivery of GDNF may be an efficacious means by which to upregulate impaired dopaminergic function in patients with PD.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE