Repletion of Zinc and Iron Deficiencies Improve Cognition of Premenopausal Women
Annual rept. 22 Sep 1997-21 Sep 1998,
TEXAS UNIV AT GALVESTON
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Primary Hypothesis Repletion of mild zinc Zn iron Fe deficiencies will improve neuropsychological performance of women. Design This is a 16 week double-blind stratified randomized controlled treatment Rx trial with a Rx cross-over at 8 weeks. Subjects are 60 Zn Fe deficient D 20 normal N premenopausal women. Before baseline measurements, other potentially limiting nutrients are repleted. Rx includes micronutrients M alone, given to 20 D 20 N subjects for 16 weeks with a pseudo-cross-over at 8 weeks 30 mg Zn with M, and 30 mg Fe with M, each given to 40 D subjects for 8 weeks, 20 subjects at a time. Outcomes -- include Zn Fe status, lean body mass LBM, Zn kinetics. other indices that might be affected by Zn status, and - neuropsychological performance. Results Screening plasma zinc concentration in 73 subjects since start was mean i SD 712 i 85.1 microgramL. Hair zinc concentrations in 102 subjects since start were 174 - 65.4 microgramgram. Platelet, leukocyte andor lymphocyte Zn concentrations were generally within the reference range.
- Medicine and Medical Research