Measurements of Dioxin, PCB and Organochlorine Levels in Breast Adipose Tissue from Women with and Without Breast Cancer.
Annual rept. 16 Oct 97-15 Oct 98
PUBLIC HEALTH INST BERKELEY CA
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This study explores associations between breast cancer and body burdens of organochiorine chemicals, including dioxins, PCBs and pesticides. The targeted chemicals are lipophilic, bioaccumulate in adipose tissue, and have carcinogenic, estrogenic or anti-estrogenic properties. Cases arc women with malignant disease and controls are women with benign histologic changes. Samples of breast adipose are obtained during surgery. Preliminary results indicate low to moderate levels of most target chemicals, comparable to levels reported in other similar studies. The most prevalent pesticides are p,p-DDE, trans-nonachldr and oxychlordane. The most prevalent PCBs are 153, 180, and 138. Octa-, Hepta- and Hexa-Dioxins and Penta-Furan are the major Dioxin congeners. A wide range of lipid content was observed, mandating expression of results on a lipid basis. At the conclusion of the study, 50 eases will be compared to 50 controls. Body burdens will be contrasted and chemicals associated with disease will be identified, relative risks estimated and dose-response relationships- established. Reduction of exposures to such chemicals could provide a means for primary prevention of breast cancer. Additionally, screening measures targeting women with an elevated body burden of such chemicals could enhance earlier detection of breast cancer, therefore decreasing morbidity and mortality.
- Anatomy and Physiology
- Medicine and Medical Research