Effect of DHEA on Bone in Young Adults
Annual rept. 1 Sep 98-31 Aug 99
BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
Pagination or Media Count:
Peak bone mass is achieved during young adulthood, accompanying marked rises in gonadal and adrenal steroids E.G., DEHYDROEPIANDROSTERONE-SULPHATE, DHEAS and insulin-like growth factors IGF-1. In these studies, we will test the hypothesis that DHEA increases bone mass through anabolic e.g.,IGF-1, and antiosteolytic e.g., interleukins mechanisms as follows Specific Aim I--to measure the effects of DHEA on bone and the regulation of androgens, lGF-1, and cytokines in anorexic women who have increased fracture risk. Data in 36 women enrolled in year 1 showed subnormal serum levels of DHEAS, lGF-I, and bone formation markers, and elevated urinary bone resorption markers. Low levels of DHEA-S were associated with elevated bone resorption markers. Specific Aim II--to measure the effects of DHEA on bone, cytokines, and growth factors in women with accelerated bone loss from treatment with gonadotropin-releasing hormone agonist GnRH assays are being pooled for measurement in subsequent years. Specific Aim III-to determine whether cytokine production andor osteoclastogenesis is downregulated by DHEA andor gonadal steroids. The studies from human marrow cultures revealed that testosterone and DHEA suppress production of lL-6. These clinical and basic studies will provide new information on the mechanisms whereby DHEA and sex steroids affect bone.
- Anatomy and Physiology
- Medicine and Medical Research