Accession Number:

ADA374231

Title:

Strategy Toward the Total Synthesis of Epothilones A and B

Descriptive Note:

Annual rept. 1 Jul 1998-30 Jun 1999

Corporate Author:

SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s):

Report Date:

1999-07-01

Pagination or Media Count:

108.0

Abstract:

Epothilones are a class of promising anti breast cancer candidate. They were synthesized by four strategies. Structure - activity relationships were studied with the synthetic compounds. The first in vivo test of synthetic epothilone D is encouraging.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE