Accession Number:

ADA374142

Title:

Bone-97 Alcohol and Skeletal Adaptation to Mechanical Usage.

Descriptive Note:

Annual rept. 1 Sep 98-31 Aug 99

Corporate Author:

MAYO CLINIC ROCHESTER MN

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

28.0

Abstract:

These studies are designed to determine whether ethanol antagonizes the ability of the skeleton to adapt to increased mechanical usage. Ethanol reversibly alters the biophysical properties of cell membranes. The overall hypothesis to be tested in adult rats is that these membrane changes disrupt essential cell signaling pathways for one or more cytokines, growth factors and polypeptide hormones that regulate bone modeling and remodeling. This report summarizes our progress from the award date November 1998 through August 31, 1999. During Year 1 of the award we have made progress in completing Tasks 1-5, and Task 8. These tasks include determination of the dose response and time course effects of administered ethanol Tasks 1 and 2 on blood alcohol levels, serum chemistry and bone metabolism determination of which induces a more detrimental skeletal response peak blood concentration of ethanol or chronic elevation of blood alcohol Task 3 evaluation of the long-term skeletal effects of ethanol on bone metabolism and strength Task 4 determination of the effects of ethanol on the skeletal adaptation resistance exercise training Task 5 determination of the effects of prior consumption of ethanol or PTH-induced increases in mRNA levels for bone matrix proteins Task 8.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE