Genes Controlling Susceptibility to Mammary Cancer.
Annual rept. 1 Jul 98-30 Jun 99
TUFTS UNIV BOSTON MA
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This report documents results from DAMD17-97-1-7123. which is designed to identify nutritionally modulated genetic loci in the mouse that alter susceptibility to breast cancer. Calorie restriction CR is a potent nutritional intervention, well documented to reduce carcinogen induced mammary tumors in rodents. The study underway is currently documenting the relative mammary tumor prevalence in 8 inbred strains of mice after being dosed with carcinogen. The mice in each genotype have been divided into two dietary groups, control and CR. CR has been successfully implemented in all strains after the mice were treated with carcinogen, demonstrating the feasibility of this nutritional intervention after carcinogen treatment. Although CR has resulted in statistically significant reductions in body weight. only 7 out of S strains demonstrate significant increases in longevity. In terms of tumorigenesis, this study has demonstrated genotypic specificity in the response of mice to carcinogen exposure. Taken together, these observations will be valuable in the search for gene controlling the effects on breast cancer of nutrition intervention.
- Anatomy and Physiology
- Medicine and Medical Research