A Comparison of Cerebral Blood Flow in Migraineurs During Headache, Headache-Free and Treatment Periods
Final rept. 15 Sep 1995-31 Dec 1998
BUFFALO INST FOR MEDICAL RESEARCH NY
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The pathophysiology of migraine remains poorly understood. Sumatriptan has been reported to increase flow velocities in large cerebral arteries, consistent with a vasoconstrictive effect. We report data from a study of tissue cerebral blood flow CBF in migraine following treatment with sumatriptan. Methods Otherwise healthy patients with a minimum of one migraine headache per month IHS criteria were scanned using H215O, and positron emission tomography, within 24 hours of the onset of migraine headache. Patients were reimaged 0.25, 0.5 and 1 hours following 6 mg SQ sumatriptan, and after a headache free interval of at least 48 hours.
- Anatomy and Physiology
- Medicine and Medical Research