Accession Number:

ADA371793

Title:

The Layman's Guide to Toxicology

Descriptive Note:

Special rept. Dec 95-Jun 99

Corporate Author:

CHEMICAL PROPULSION INFORMATION AGENCY COLUMBIA MD

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

90.0

Abstract:

The science of toxicology has changed dramatically since the discipline was formally founded. The use of animal models in toxicity testing is still the method of choice for assessing the hazards associated with exposure to chemical compounds. A broad scope of approaches to toxicity testing provides data ranging from acute lethality to organ-specific toxicity e.g.. reproductive effects to carcinogenicity. Although the use of animal models dominates many toxicology studies, many in vitro alternatives to animal use have been developed over the past two decades. A full gambit of toxicity tests, including both in vivo and in vitro assays, serve as the foundation for evaluation of chemicals. Safety evaluation and risk assessment processes draw on several basic science fields. Data from toxicity tests serves in combination with other information, such as exposure data and the biology sensitive populations. in the risk assessment process. Risk assessment weighs heavily in setting regulatory standards. The Laymens Guide to Toxicology summarizes the major concepts of this science as they relate to technical, non-science industrial professionals. The Guide is written by toxicologists and industrial hygienists and is aimed at conveying the important aspects of toxicology to other industrial professionals in an effort to bridge the gap between technical disciplines. The Guide was prepared under the auspices of the Joint Army-Navy-NASA-Air Force JANNAF Interagency Propulsion Committee - Safety Environmental Protection Subcommittee, for use as a reference for the propulsion community.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE