Cytokines, Neovascularization and Breast Cancer
Annual rept. 1 Oct 97-30 Sep 98
CONNECTICUT UNIV HEALTH CENTER FARMINGTON
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In some respects, tumors and wounds behave in a similar fashion. Among other things, both require the in growth of new blood vessels either to establish healing, or in the case of tumors, to promote tumor growth and metastasis. Our central hypothesis in this study is that tumors express angiogenic factors, and respond abnormally to such factors. In previous work, we established the presence of IL-8, a known angiogenic factor in human breast cancers. This was measured in samples from human tumors, and measured in vitro from human breast cancer cells. This report covers our initial attempts at establishing an in vivo model of human breast cancer, and studies using anti-angiogenesis agents. During the course of this Task, numerous methodological problems were encountered that needed to be resolved. Once these were overcome, we were able to reliably grow the tumor cell lines in immunodeficient mice. Mice were then treated with specific and non-specific inhibitors. Preliminary results demonstrated inhibition of tumor growth by both anti IL-8 antibodies, and thalidomide. This effect was lost at later time points. These studies, and future plans are described. Work is ongoing.
- Anatomy and Physiology
- Medicine and Medical Research