Identification of Novel Candidate Tumor Suppressor Genes Using C. elegans as a Model.
Annual rept. 1 Nov 97-31 Oct 98
CALIFORNIA INST OF TECH PASADENA
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Molecular genetic analysis of the model organism Caenorhabditis elegans was used to identify and study mechanisms of action of negative regulators of tyrosine kinaseRAS mediated signal transduction that are candidate tumor suppressors. A homolog of the proto oncogene cbl, SLI-1, inhibits Ras activation by the epidermal growth factor receptor homolog LET-23. A missense mutation in the RING finger region of SLI-1 has been identified and provides are reagent to analyze the function of this domain. New screens for additional negative regulators have identified at least four genes that are now being analyzed.
- Anatomy and Physiology
- Medicine and Medical Research