Accession Number:

ADA371252

Title:

Role of Tumor Collagenase Stimulating Factor in Breast Cancer Invasion and Metastasis.

Descriptive Note:

Annual rept.,

Corporate Author:

STATE UNIV OF NEW YORK AT STONY BROOK RESEARCH FOUNDATION

Personal Author(s):

Report Date:

1998-12-01

Pagination or Media Count:

67.0

Abstract:

Extracellular matrix metalloproteinase inhibitor EMMPRIN, a plasma membrane glycoprotein identified originally in carcinoma cells, is responsible for inducing peritumoral fibroblasts to produce matrix metalloproteinases MMPs, thereby enhancing cancer invasion and metastasis. Using in situ hybridization and immunohistochemistry, we have identified EMMPRIN in breast cancer tissue. We have characterized the human EMMPRIN gene and have noted a high degree of conservation with the mouse gene.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE