Accession Number:

ADA371201

Title:

DNA Topoisomerase I-Targeted Therapy for Breast Cancer

Descriptive Note:

Annual rept. 6 May 98-5 May 99

Corporate Author:

CANCER THERAPY AND RESEARCH FOUNDATION SAN ANTONIO TX

Personal Author(s):

Report Date:

1999-06-01

Pagination or Media Count:

34.0

Abstract:

The specific aim of this work is to develop camptothecin CPT analogs for treatment of women with breast cancer. We evaluated these analogs using three biochemical tests 1 inhibition of growth of breast cancer cells, 2 induction of topoisomerase I-mediated cleavage of DNA, and 3 reversal of DNA cleavage. Our results indicate that the 10,11-methylenedioxy CPT analog was effective in all three tests. Further, this analog was effective against MX-1 and MDA-231 human breast xenografts growing in nude mice. The 10, 11- methylenedioxy analog appears to be the best choice among the analogs examined, and we are currently pursuing moving this compound into clinical trials.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE