Accession Number:

ADA371168

Title:

Cell-Cell Adhesion and Breast Cancer.

Descriptive Note:

Annual rept. 15 Dec 97-14 Dec 98

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

1999-01-01

Pagination or Media Count:

159.0

Abstract:

The objective of this proposal is to elucidate the role of cell-cell adhesion and calcium dependent cell adhesion molecules cadherins in breast tumor progression. We will test the hypothesis that in addition to the occasional loss of E-cadherin expression, breast tumor progression is more realistically modeled by a loss of strong cell-cell adhesion resulting from defects in any one or more of the steps molecules required for E-cadherin function. During the past year we have we published findings showing that invasive E-cadherin negative breast cancer cells express the mesenchymal cadherin, cadherin 11 which may well contribute to the invasive phenotype. Retinoid treatment was found to directly regulate Beta-cateninLEF signaling in a manner independent of cadherin function. We showed for the first time that Beta-catenin regulates contact inhibition, anchorage independent growth, anoikis and radiation-induced growth arrest. The tumor suppressor gene APC was shown to regulate Beta-catenin ubiquitination and degradation.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE