Accession Number:

ADA371063

Title:

Modification and Control of Wound Healing in Tracheobronchial Injuries Using Minimally Invasive Surgical Techniques and Biologic Growth Factors-CIC3.

Descriptive Note:

Final rept. 1 Sep 97-14 Nov 98

Corporate Author:

ALBANY MEDICAL COLL NY

Personal Author(s):

Report Date:

1998-11-01

Pagination or Media Count:

35.0

Abstract:

Tracheobronchial injury is associated with significant morbidity and mortality. Morbidity occurs both early and late i.e. airway stenosis. Current treatment options for post traumatic tracheal lesions include surgical resection or endoscopic repair. Commonly, surgery is necessary after endoscopic management fails from restenosis. However, surgical resection can have a similar outcome. Currently, metallic stents offer an adjunctive treatment in airway reconstruction. These stents have the capability of stabilizing the size of the airway lumen, while preventing surgical site restenosis. Our study evaluated the mucosal injury and subsequent wound healing associated with tracheal stent placement. Additionally the addition of topical MTC to the operative site in laryngotracheal reconstruction resulted in improved graft incorporation. Wound healing is a complex interaction regulated by growth factors, which can be modulated by fibroblast inhibitors i.e. MTC. Controlling postoperative scarring in airway reconstruction would dramatically impact treatment of these injuries. Continued evaluation of airway wound healing in an animal model using these devices and biologic modulators is key in understanding the optimum means of early and late repair of airway injuries.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE