Accession Number:

ADA370331

Title:

Attenuation of Brain Hyperbaric Oxygen Toxicity of Fasting is Not Related to Ketosis

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER BETHESDAMD

Personal Author(s):

• Chavko, M.
• Braisted, J. C.
• Harabin, A. L.

Report Date:

1999-02-01

Pagination or Media Count:

7.0

Abstract:

The objective of this study was to determine if protection from HBO2 seizures by acute, short fasting is related to the ketosis or to the mild hypoglycemia resulting from this treatment, or to both. For this purpose, blood glucose and ketone levels were manipulated in the fed and fasted rats by injection of glucose or a ketone precursor, 1,3- butanediol BD, and the latency to seizures was recorded.

Descriptors:

• *BRAIN
• *FOOD DEPRIVATION
• *HYPERBARIC CONDITIONS
• STARVATION
• OXYGEN
• ATTENUATION
• CIRCULATION
• CENTRAL NERVOUS SYSTEM
• GLUCOSE
• KETONES
• CONVULSIVE DISORDERS
• BLOOD CHEMISTRY
• HYPOGLYCEMIA

Subject Categories:

• Medicine and Medical Research
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE