Accession Number:

ADA370330

Title:

Raid 4D MRI of GAD-DTPA Enhancement for Breast Lesion Characterization

Descriptive Note:

Final rept. 1 Oct 94-31 Mar 99

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

Report Date:

1999-04-01

Pagination or Media Count:

29.0

Abstract:

The aims of this project were refinement and implementation of new methods designed to defeat the tradeoff between spatial resolution, temporal resolution and tissue coverage in dynamic gadolinium-enhanced MR mammography. The approach involved specialized software for data acquisition and reconstruction to yield dynamic scans of 32 sections through both breasts acquired at 5-6 second temporal resolution. Additional post-processing reduced motion artifacts for improved quantitation via in numerical fitting of temporal enhancement properties of tissues. Technical objectives related to completion of data acquisition and processing methods were generally successful. This methodology was applied in a prospective 4-year study of 102 women referred for surgical biopsy of a breast abnormality detected by non-MRI means. The hypothesis that malignancies to will display a high contrast-enhancement rate was supported by the data RATE 79 - 75X10EXP -3SEC, MEAN - STD DEV, N39 relative to benign tissues RATE 19 - 16X10EXP -3SEC, N54, although some overlap exists. ROC analysis yields a sensitivity 85 and specificity 75 using an enhancement-rate threshold 22x10exp -3sec. These quantitative kinetic properties can be further combined with tissuelesion morphology to further enhance specificity of breast MRI.

Subject Categories:

  • Medicine and Medical Research
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE