Genetic Epidemiology of in situ Breast Cancer
Annual rept. 15 Nov 1997-14 Nov 1998
YALE UNIV NEW HAVEN CT
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This five year project will define risk factors associated with breast carcinoma in-situ through the mechanism of a casecontrol study. The study population consists of approximately 1100-1200 cases of female breast carcinoma in- situ BCIS and 1100-1200 age-matched female controls selected from the state of Connecticut. At the end of year four, case and control ascertainment is complete with 1537 eligible cases and 1285 eligible controls identified. Physicians have consented for 91 of eligible cases. Eighty-seven percent of contacted eligible cases and 85 of contacted eligible controls have agreed to participate in telephone interviews which collect information concerning family history of cancer, pregnancy and menstrual history, hormone replacement therapy, oral contraceptive use, fertility drug use, as well as sociodemographic variables. Preliminary analyses suggest that many of the risk factors traditionally associated with invasive breast cancer, including a family history of breast cancer, are also associated with the development of BCIS. In addition to the interview portion of the study, which is now essentially complete, the expression of p53, c-erbB-2 as well as estrogen and progesterone receptors will be examined in paraffin-blocks from a subset of cases.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research