Accession Number:

ADA367421

Title:

Perchlorate Literature Review and Summary: Developmental Effects, Metabolism, Receptor Kinetics and Pharmacological Uses.

Descriptive Note:

Interim rept. Jun 97-Jul 98,

Corporate Author:

OPERATIONAL TECHNOLOGIES CORP DAYTON OH

Personal Author(s):

• Sterner, Teresa R.
• Mattie, David R.

Report Date:

1998-08-01

Pagination or Media Count:

57.0

Abstract:

Perchlorate is a monovalent anion found as a soil and groundwater contaminate on government contractor sites and, more recently, on an Air Force site. Perchlorate is dissociated from the salt, ammonium perchlorate, which is an efficient oxidizer used in solid rocket propellant systems. This review was undertaken to evaluate the available information on developmental and reproductive effects, thyroid iodide receptor kinetics, pharmacological uses of perchlorate outside the treatment of Graves disease, and absorption, distribution, metabolism and excretion of perchlorate. Summarization of the available information and conclusions make the data more accessible to toxicologists and review panels for consideration in study prioritization and future reference dose development.

Descriptors:

• *CHEMICAL CONTAMINATION
• *MEDICAL RESEARCH
• *BIOLOGICAL ABSORPTION
• *AMMONIUM PERCHLORATE
• METABOLISM
• GROUND WATER
• AIR FORCE FACILITIES
• KINETICS
• SOIL POLLUTION
• PHARMACOLOGY
• SOLID ROCKET PROPELLANTS
• TOXICOLOGISTS
• EXCRETION

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE