Accession Number:

ADA364762

Title:

Preparation of Chemicals and Bulk Drug Substances for the U.S. Army Drug Development Program.

Descriptive Note:

Final rept. 1 Dec 92-31 Mar 99,

Corporate Author:

STARKS ASSOCIATES INC BUFFALO NY

Personal Author(s):

Report Date:

1999-05-01

Pagination or Media Count:

109.0

Abstract:

One hundred and ten candidate drugs or their intermediates have been prepared during the duration of this contract. Twenty-one of these materials are new to the chemical literature. A new route has been developed for a large scale production of HI-6. The synthesis of IND artelinic acid has been improved with large savings in material and labor costs. The control of purity of candidate drugs has been a prime objective of the contract. Rigorous detailed procedures have been developed to permit the definition of drug quality. Criteria used for purity definition consisted of elementary constitution analysis, chromatographic homogeneity, and infrared, ultraviolet and 500 MHz high resolution nmr spectra. If required, mass spectra, and high pressure liquid chromato-graphy NPLC was also used. A broad spectrum of materials have been prepared during the six and one third year contract period. The type of requested materials were divided as follows isoquinolinones, qinghaosu derivatives, quaternary anticholinesterase reacti-vators, triazines and derivatives, quinazolines and derivatives, camptothecin derivatives and intermediates, infectious disease related compounds and intermediates, chemical defense related compounds and intermediates and carbocyclic nucleosides.

Subject Categories:

  • Medical Facilities, Equipment and Supplies
  • Pharmacology
  • Military Operations, Strategy and Tactics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE