Beta Catenin-Regulated Genes in Breast Cancer.
Annual rept. 1 Aug 97-31 Jul 98
GEORGETOWN UNIV WASHINGTON DC
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Mutations of the APC tumor suppressor gene are linked to a number of hyperplastic events in humans and in mice, including breast cancer. Recent evidence indicates that the APC gene product may play an active role in the wnt-1 signaling pathway as a regulator of cytoplasmic B-catenin, a known mediator of transcription. Cytoplasmic B-catenin signaling may contribute to the transformation of cancerous cells, mediating the acquisition of a more aggressive, invasive phenotype. This project proposes to identify genes which may be regulated by B-catenin by using a novel method called gene-trapping, as well as through investigation of several best guess genes, including Leukemia Inhibitory Factor LIF. Characterization of these genes will potentially elucidate another portion of the wnt-1 signaling pathway, and give fresh insight into the exact nature of the cell cycle perturbations caused by B-catenin and other components of the pathway.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research