Role of MYC in Anchorage-Dependent Growth
Annual rept. 1 Sep 97-31 Aug 98
GEORGETOWN UNIV WASHINGTON DC
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When deprived of adhesion to a solid substrate, fibroblasts are unable to proliferate and arrest in the G1 phase of the cell cycle. We have shown that there is a similar adhesion -responsive G1 restriction point in the immortalized human mammary epithelial cells line, 184A1N4. Unlike normal cells, transformed cells gain the ability to bypass this integrin-mediated control of proliferation and to grow in an anchorage-independent manner. We are examining the effect of c-Myc overexpression, which frequently occurs in breast cancer, in the adhesion-dependent regulation of the Gl-S phase transition.
- Anatomy and Physiology
- Medicine and Medical Research