Accession Number:

ADA364661

Title:

Role of MYC in Anchorage-Dependent Growth

Descriptive Note:

Annual rept. 1 Sep 97-31 Aug 98

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

1998-09-01

Pagination or Media Count:

13.0

Abstract:

When deprived of adhesion to a solid substrate, fibroblasts are unable to proliferate and arrest in the G1 phase of the cell cycle. We have shown that there is a similar adhesion -responsive G1 restriction point in the immortalized human mammary epithelial cells line, 184A1N4. Unlike normal cells, transformed cells gain the ability to bypass this integrin-mediated control of proliferation and to grow in an anchorage-independent manner. We are examining the effect of c-Myc overexpression, which frequently occurs in breast cancer, in the adhesion-dependent regulation of the Gl-S phase transition.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE