Accession Number:

ADA361846

Title:

Analysis of Phenotypic Variability in Neurofibromatosis, Type 1.

Descriptive Note:

Annual rept. 30 Sep 97-29 Sep 98,

Corporate Author:

BRITISH COLUMBIA UNIV VANCOUVER

Personal Author(s):

• Friedman, Jan M.

Report Date:

1998-10-01

Pagination or Media Count:

53.0

Abstract:

The clinical manifestations of NF1 are extremely variable. The purpose of this project is to characterize the sources of phenotypic variability in NF1 by using a combination of clinical, statistical, epidemiological, and molecular genetic methods. Our studies to date have included analysis of possible associations among all clinical features by simple 2x2 Xexp 2 analysis and more detailed analysis of selected features for the effects of covariates using stratification and log-linear methods. We found that age does not have a uniform effect on each variable and have developed a strategy using various approaches including linear regression to deal with this problem in future analyses. We have developed a list of possible clinical subtypes of NF1.

Descriptors:

• *NERVOUS SYSTEM
• *GENETICS
• MOLECULES
• CLINICAL MEDICINE
• NERVOUS SYSTEM DISEASES
• MOLECULAR BIOLOGY
• STATISTICAL ANALYSIS
• LINEAR REGRESSION ANALYSIS
• STRATIFICATION
• EPIDEMIOLOGY
• PERIPHERAL NERVOUS SYSTEM

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE