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Accession Number:
ADA361846
Title:
Analysis of Phenotypic Variability in Neurofibromatosis, Type 1.
Descriptive Note:
Annual rept. 30 Sep 97-29 Sep 98,
Corporate Author:
BRITISH COLUMBIA UNIV VANCOUVER
Report Date:
1998-10-01
Pagination or Media Count:
53.0
Abstract:
The clinical manifestations of NF1 are extremely variable. The purpose of this project is to characterize the sources of phenotypic variability in NF1 by using a combination of clinical, statistical, epidemiological, and molecular genetic methods. Our studies to date have included analysis of possible associations among all clinical features by simple 2x2 Xexp 2 analysis and more detailed analysis of selected features for the effects of covariates using stratification and log-linear methods. We found that age does not have a uniform effect on each variable and have developed a strategy using various approaches including linear regression to deal with this problem in future analyses. We have developed a list of possible clinical subtypes of NF1.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE