Genetic Immunization for Lentiviral Immunodeficiency Virus Infection and Disease
Final rept. 30 Sep 94-29 Oct 98
CALIFORNIA UNIV DAVIS
Pagination or Media Count:
We vaccinated 4 groups of macaques with several forms of SIV envelope antigens expressed from plasmid DNA. One group was later boosted with recombinant protein antigen and another group was further vaccinated with a noninfectious proviral DNA. We found protection in approximately half of the animals after oral challenge with pathogenic SlVMAC 251. All 4 unvaccinated control animals were infected. Two different forms of protection were observed. Two animals did not have any detectable virus at any time after challenge. Three other animals developed an initial acute viremia but slowly cleared the virus. None of the protected animals showed any sign of clinical disease and T cell levels remained normal. Animals boosted with protein showed increased viral load and early progression to disease.
- Medicine and Medical Research