Accession Number:

ADA361599

Title:

Transgenic Repository for Breast Cancer Research

Descriptive Note:

Final rept. 1 Jun 94-31 May 98

Corporate Author:

JACKSON LAB BAR HARBOR ME

Personal Author(s):

• Davisson, Muriel T.

Report Date:

1998-07-01

Pagination or Media Count:

20.0

Abstract:

The overall goal of this project is to develop and maintain a resource of mouse models for breast cancer research. Forty-five strains carrying induced mutations have been identified and accepted for importation into The Jackson Laboratory TJL Induced Mutant Resource IMR repository for breast cancer research models. The importation process frees mice of infectious pathogens. Embryos or gametes are cryopreserved. Correct nomenclature is assigned, efficient breeding strategies are developed, and genotyping protocols are modified for optimal efficiency and accuracy. Strain availability is announced in several media, including a page on the IMRs World Wide Web site, accessed through TJLs WwW home page. A principal aim of this project is to transfer relevant mutations to a defined genetic background. Nine mutations are being transferred, including 7 to the FVBNJ inbred background. Reports by others and our own observations suggest that tumor characteristics may be altered as a consequence of background strain modifiers. Congenic strains require characterization of tumor onset and type.

Descriptors:

• *MUTATIONS
• *GENETICS
• *BREAST CANCER
• GLOBAL
• NEOPLASMS
• MICE
• INFECTIOUS DISEASES
• MEDICAL RESEARCH
• EMBRYOS
• INTERNET
• PATHOGENIC MICROORGANISMS
• BREEDING
• GERM CELLS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE